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Bas-Congo virus
The Bas-Congo virus (BASV), named after the DRC's area of Bas-Congo, in which it was first discovered, is a novel rhabdovirus associated with a small outbreak of hemorrhagic fever in Mangala village in 2009. The disease is characterized by a fulminant course and can be fatal. In the 2009 outbreak, two out of three people died. The surviving patient and a further asymptomatic person developed antibodies against BASV.
== Discovery ==
The virus was discovered after the exclusion of all known viral agents causing hemorrhagic fever. RNA copies of BASV were found in the serum of the patient who survived the disease. The genome was assembled using the deep sequencing method. Phylogenetic analysis revealed rather big differences to other known rhabdoviruses. Two people, a surviving nurse and a close contact, developed antibodies highly specific for the BASV glycoprotein (BASV-G). Neutralization was observed only with BASV-G and not with pseudoviruses carrying the glycoprotein of the related'' ''rhabdovirus vesicular stomatitis virus (VSV-G) thus indicating that BASV was the actual cause of the outbreak.
A rhabdovirus causing hemorrhagic fever in humans seems strange at first glance for no member of this family has been associated with this kind of disease in humans before. However, fish can suffer from viral hemorrhagic septicemia, a disease caused by a member of the ''novirhabdovirus'' genus that leads to bleedings. Most relevant to humans are the different species of the genus ''lyssavirus'' causing rabies.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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